The Effect of Antenatal
L-Arginine and Antioxidant Supplementation on Oxidative
Stress Marker Levels in Newborns
Published: October 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.4966
Shweta Dr, Khanna Anuradha
1. Assistant Professor, Department of Obstetrics and Gynaecology, Mgmcri, Pondicherry, India.
2. Professor, Department of Obstetrics and Gynaecology, Institute of Medical Sciences, Bhu, Varanasi, India.
Correspondence
Dr. Shweta,
C/O Dr Sanchit Gupta, Married Senior Resident Quarters No 24, Jipmer Campus, Gorimedu, Pondicherry, India.
Phone : 9442489104, E-mail : Shwetaguptadr15@gmail.com
Introduction:The present study was conducted in the Department of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with an aim to study the role of L-arginine and oral antioxidants as a part of therapy in patients diagnosed with IUGR (Intra uterine growth restriction ) and cord serum NO and oxidative stress markers GSH and SOD in newborns following delivery of such patients.
Materials and Methods: The study included 40 pregnant patient between 30-32 weeks of gestation diagnosed with IUGR who were divided into 3 groups: Group I (treated with L-arginine N=10), Group II (treated with antioxidants N=10), Group III (without nutritional supplementation N=10) and Group IV (healthy control pregnant patients of same gestational age range N=10) were taken. Cord serum NO & oxidative stress markers (GSH & SOD) were measured following delivery of patients from those four groups.
Results: The cord serum NO levels (µmol/lt) showed a significant increase & SOD (U/ml) & GSH (U/lt) values were increased in newborns to mothers diagnosed with IUGR after treatment with L-arginine. Similar results were obtained for treatment with antioxidants.
Conclusion: The reduced NO & reduced cord serum circulating levels of oxidative stress markers (GSH & SOD) activity may play an important role in the occurrence of IUGR.
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